Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses

7α,25-dihydroxycholesterol (7α,25-OHC) is a ligand for the G-protein coupled receptor EBI2 (GPR183); however, the cellular sources of this oxysterol are undefined. 7α,25-OHC is synthesized from cholesterol by the stepwise actions of two enzymes, CH25H and CYP7B1, and is metabolized to a 3-oxo deriva...

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Detalhes bibliográficos
Main Authors: Yi, Tangsheng, Wang, Xiaoming, Kelly, Lisa M., An, Jinping, Xu, Ying, Sailer, Andreas W., Gustafsson, Jan-Ake, Russel, David W., Cyster, Jason G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465460/
https://ncbi.nlm.nih.gov/pubmed/22999953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2012.06.015
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