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Position-dependent correlations between DNA methylation and the evolutionary rates of mammalian coding exons

DNA cytosine methylation is a central epigenetic marker that is usually mutagenic and may increase the level of sequence divergence. However, methylated genes have been reported to evolve more slowly than unmethylated genes. Hence, there is a controversy on whether DNA methylation is correlated with...

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Autori principali: Chuang, Trees-Juen, Chen, Feng-Chi, Chen, Yen-Zho
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465446/
https://ncbi.nlm.nih.gov/pubmed/23019368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1208214109
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