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Parameter-free model discrimination criterion based on steady-state coplanarity

We introduce a procedure for deciding when a mass-action model is incompatible with observed steady-state data that does not require any parameter estimation. Thus, we avoid the difficulties of nonlinear optimization typically associated with methods based on parameter fitting. Instead, we borrow id...

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Detalhes bibliográficos
Main Authors: Harrington, Heather A., Ho, Kenneth L., Thorne, Thomas, Stumpf, Michael P.H.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465434/
https://ncbi.nlm.nih.gov/pubmed/22967512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1117073109
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