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Oxidative Stress Induced Inflammation Initiates Functional Decline of Tear Production

Oxidative damage and inflammation are proposed to be involved in an age-related functional decline of exocrine glands. However, the molecular mechanism of how oxidative stress affects the secretory function of exocrine glands is unclear. We developed a novel mev-1 conditional transgenic mouse model...

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Detalhes bibliográficos
Main Authors: Uchino, Yuichi, Kawakita, Tetsuya, Miyazawa, Masaki, Ishii, Takamasa, Onouchi, Hiromi, Yasuda, Kayo, Ogawa, Yoko, Shimmura, Shigeto, Ishii, Naoaki, Tsubota, Kazuo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465290/
https://ncbi.nlm.nih.gov/pubmed/23071526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045805
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