Nicotine, IFN-γ and retinoic acid mediated induction of MUC4 in pancreatic cancer requires E2F1 and STAT-1 transcription factors and utilize different signaling cascades

BACKGROUND: The membrane-bound mucins are thought to play an important biological role in cell–cell and cell–matrix interactions, in cell signaling and in modulating biological properties of cancer cell. MUC4, a transmembrane mucin is overexpressed in pancreatic tumors, while remaining undetectable...

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Autors principals: Kunigal, Sateesh, Ponnusamy, Moorthy P, Momi, Navneet, Batra, Surinder K, Chellappan, Srikumar P
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2012
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464875/
https://ncbi.nlm.nih.gov/pubmed/22537161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-11-24
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