Administration of Anti-CD3 Antibodies Modulates the Immune Response to an Infusion of α-glucosidase in Mice

Animal and human studies of enzyme replacement therapy (ERT) for Pompe disease (PD) have indicated that antibodies (Abs) generated against infused recombinant human α-glucosidase (rhGAA) can have a negative impact on the therapeutic outcome and cause hypersensitivity reactions. We showed that parent...

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Detalhes bibliográficos
Main Authors: Ohashi, Toya, Iizuka, Sayoko, Shimada, Yohta, Higuchi, Takashi, Eto, Yoshikatsu, Ida, Hiroyuki, Kobayashi, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464650/
https://ncbi.nlm.nih.gov/pubmed/22871665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.133
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