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The Endocannabinoid, Anandamide, Augments Notch-1 Signaling in Cultured Cortical Neurons Exposed to Amyloid-β and in the Cortex of Aged Rats

Aberrant Notch signaling has recently emerged as a possible mechanism for the altered neurogenesis, cognitive impairment, and learning and memory deficits associated with Alzheimer disease (AD). Recently, targeting the endocannabinoid system in models of AD has emerged as a potential approach to slo...

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Autori principali: Tanveer, Riffat, Gowran, Aoife, Noonan, Janis, Keating, Sinead E., Bowie, Andrew G., Campbell, Veronica A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464574/
https://ncbi.nlm.nih.gov/pubmed/22891244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.350678
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