Inactivation of the Heme Degrading Enzyme IsdI by an Active Site Substitution That Diminishes Heme Ruffling

IsdG and IsdI are paralogous heme degrading enzymes from the bacterium Staphylococcus aureus. Heme bound by these enzymes is extensively ruffled such that the meso-carbons at the sites of oxidation are distorted toward bound oxygen. In contrast, the canonical heme oxygenase family degrades heme that...

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Bibliographic Details
Main Authors: Ukpabi, Georgia, Takayama, Shin-ichi J., Mauk, A. Grant, Murphy, Michael E. P.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464526/
https://ncbi.nlm.nih.gov/pubmed/22891243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.393249
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