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Precise Regulation of Porcupine Activity Is Required for Physiological Wnt Signaling
Gradients of diverse Wnt proteins regulate development, renewal, and differentiation. Porcupine (PORCN) is a membrane-bound O-acyltransferase that is required for post-translational modification of all Wnts to enable their transport, secretion, and activity. Mutations in PORCN are associated with fo...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3464525/ https://ncbi.nlm.nih.gov/pubmed/22888000 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.381970 |
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