Ventricular Assist Device Implantation Corrects Myocardial Lipotoxicity, Reverses Insulin Resistance and Normalizes Cardiac Metabolism in Patients with Advanced Heart Failure

BACKGROUND: Heart failure is associated with impaired myocardial metabolism with a shift from fatty acids to glucose utilization for ATP generation. We hypothesized that cardiac accumulation of toxic lipid intermediates inhibits insulin signaling in advanced heart failure and that mechanical unloadi...

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Auteurs principaux: Chokshi, Aalap, Drosatos, Konstantinos, Cheema, Faisal H., Ji, Ruiping, Khawaja, Tuba, Yu, Shuiqing, Kato, Tomoko, Khan, Raffay, Takayama, Hiroo, Knöll, Ralph, Milting, Hendrik, Chung, Christine S., Jorde, Ulrich, Naka, Yoshifumi, Mancini, Donna M., Goldberg, Ira J., Schulze, P. Christian
Format: Artigo
Langue:Inglês
Publié: 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464497/
https://ncbi.nlm.nih.gov/pubmed/22586279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.111.060889
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