In vitro methylation of the hamster adenine phosphoribosyltransferase gene inhibits its expression in mouse L cells.
The effect of DNA methylation on the expression of the hamster adenine phosphoribosyltransferase (aprt) gene in mouse cells has been examined. This gene was methylated in vitro at all of its C-C-G-G sites by using Hpa II methylase and was inserted into mouse Ltk- aprt- L cells by cotransformation, w...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
1982
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC346431/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6954487/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.79.11.3418 |
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