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Ordering of neuronal apoptosis signaling: a superoxide burst precedes mitochondrial cytochrome c release in a growth factor deprivation model

Axonal injury to retinal ganglion cells, a defined central neuron, induces a burst of intracellular superoxide anion that precedes externalization of membrane phosphatidylserine and subsequent apoptotic cell death. Dismutation of superoxide prevents the signal and delays loss of these cells, consist...

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Autori principali: Lieven, Christopher J., Thurber, Katherine A., Levin, Emily J., Levin, Leonard A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464307/
https://ncbi.nlm.nih.gov/pubmed/22411528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10495-012-0714-5
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