Adenovirus-Mediated Sensitization to the Cytotoxic Drugs Docetaxel and Mitoxantrone Is Dependent on Regulatory Domains in the E1ACR1 Gene-Region

Oncolytic adenoviruses have shown promising efficacy in clinical trials targeting prostate cancers that frequently develop resistance to all current therapies. The replication-selective mutants AdΔΔ and dl922–947, defective in pRb-binding, have been demonstrated to synergise with the current standar...

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Autores principales: Miranda, Enrique, Maya Pineda, Hector, Öberg, Daniel, Cherubini, Gioia, Garate, Zita, Lemoine, Nick R., Halldén, Gunnel
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463540/
https://ncbi.nlm.nih.gov/pubmed/23056370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046617
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