Human Surfactant Protein A2 Gene Mutations Impair Dimmer/Trimer Assembly Leading to Deficiency in Protein Sialylation and Secretion

Surfactant protein A2 (SP-A2) plays an essential role in surfactant metabolism and lung host defense. SP-A2 mutations in the carbohydrate recognition domain have been related to familial pulmonary fibrosis and can lead to a recombinant protein secretion deficiency in vitro. In this study, we explore...

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Bibliografski detalji
Glavni autori: Song, Yi, Fang, Guodong, Shen, Haitao, Li, Hui, Yang, Wenbing, Pan, Bing, Huang, Guowei, Lin, Guangyu, Ma, Lian, Willard, Belinda, Gu, Jiang, Zheng, Lemin, Wang, Yongyu
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463533/
https://ncbi.nlm.nih.gov/pubmed/23056344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046559
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