MEN1 gene replacement therapy reduces proliferation rates in a mouse model of pituitary adenomas

Multiple endocrine neoplasia type 1 (MEN1) is characterized by the combined occurrence of pituitary, pancreatic and parathyroid tumors showing loss of heterozygosity in the putative tumor suppressor gene MEN1. This gene encodes the protein menin, the overexpression of which inhibits cell proliferati...

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Detalhes bibliográficos
Main Authors: Walls, Gerard V., Lemos, Manuel C, Javid, Mahsa, Bazan-Peregrino, Miriam, Jeyabalan, Jeshmi, Reed, Anita A. C., Harding, Brian, Tyler, Damian J., Stuckey, Daniel J., Piret, Sian, Christie, Paul T., Ansorge, Olaf, Clarke, Kieran, Seymour, Len, Thakker, Rajesh V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463502/
https://ncbi.nlm.nih.gov/pubmed/22915754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-1821
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