Development and characterization of a new oral dapsone nanoemulsion system: permeability and in silico bioavailability studies

BACKGROUND: Dapsone is described as being active against Mycobacterium leprae, hence its role in the treatment of leprosy and related pathologies. Despite its therapeutic potential, the low solubility of dapsone in water results in low bioavailability and high microbial resistance. Nanoemulsions are...

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Detalhes bibliográficos
Main Authors: Monteiro, Lidiane M, Lione, Viviane F, do Carmo, Flavia A, do Amaral, Lilian H, da Silva, Julianna H, Nasciutti, Luiz E, Rodrigues, Carlos R, Castro, Helena C, de Sousa, Valeria P, Cabral, Lucio M
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2012
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463397/
https://ncbi.nlm.nih.gov/pubmed/23055729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S36479
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