A Novel Mechanism for Antibody-based Anthrax Toxin Neutralization: INHIBITION OF PREPORE-TO-PORE CONVERSION

Protective antigen (PA), a key component of anthrax toxin, mediates the entry of lethal factor (LF) or edema factor (EF) through a membranal pore into target cells. We have previously reported the isolation and chimerization of cAb29, an anti-PA monoclonal antibody that effectively neutralizes anthr...

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Bibliografische gegevens
Hoofdauteurs: Mechaly, Adva, Levy, Haim, Epstein, Eyal, Rosenfeld, Ronit, Marcus, Hadar, Ben-Arie, Einat, Shafferman, Avigdor, Ordentlich, Arie, Mazor, Ohad
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2012
Onderwerpen:
Microbiology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463365/
https://ncbi.nlm.nih.gov/pubmed/22869370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.400473
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