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Sustained Activation of N-Methyl-d-Aspartate Receptors in Podoctyes Leads to Oxidative Stress, Mobilization of Transient Receptor Potential Canonical 6 Channels, Nuclear Factor of Activated T Cells Activation, and Apoptotic Cell Death
Atypical N-methyl-d-aspartate (NMDA) receptors are expressed in podocytes. Sustained (≥24 h) application of 50 to 100 μM NMDA to immortalized mouse podocytes evoked a marked increase in the production of reactive oxygen species (ROS) such as H(2)O(2). This effect of NMDA was associated with increase...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3463221/ https://ncbi.nlm.nih.gov/pubmed/22828802 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.079376 |
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