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Engineering a Disulfide Bond in the Lid Hinge Region of Rhizopus chinensis Lipase: Increased Thermostability and Altered Acyl Chain Length Specificity

The key to enzyme function is the maintenance of an appropriate balance between molecular stability and structural flexibility. The lid domain which is very important for “interfacial activation” is the most flexible part in the lipase structure. In this work, rational design was applied to explore...

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Библиографические подробности
Главные авторы: Yu, Xiao-Wei, Tan, Nian-Jiang, Xiao, Rong, Xu, Yan
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2012
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3462767/
https://ncbi.nlm.nih.gov/pubmed/23056295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046388
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