CELL-SPECIFIC TRAFFICKING SUGGESTS A NEW ROLE FOR RENAL ATP7B IN THE INTRACELLULAR COPPER STORAGE

Human Cu-ATPases ATP7A and ATP7B maintain copper homeostasis through regulated trafficking between intracellular compartments. Inactivation of these transporters causes Menkes disease and Wilson disease, respectively. In Menkes disease, copper accumulates in kidneys and causes tubular damage, indica...

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Detalhes bibliográficos
Main Authors: Barnes, Natalie, Bartee, Mee Y., Braiterman, Lita, Gupta, Arnab, Ustiyan, Vladimir, Zuzel, Vesna, Kaplan, Jack H., Hubbard, Ann L., Lutsenko, Svetlana
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3462735/
https://ncbi.nlm.nih.gov/pubmed/19416479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-0854.2009.00901.x
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