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Clinical trial design in chronic obstructive pulmonary disease: current perspectives and considerations with regard to blinding of tiotropium

Randomised, double-blind, controlled trials are considered the gold standard for evaluating a pharmacological agent, as they minimise any potential bias. However, it is not always possible to perform double-blind trials, particularly for medications delivered via specific devices, e.g. inhalers. In...

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Detalhes bibliográficos
Main Authors: Beeh, Kai-Michael, Beier, Jutta, Donohue, James F
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3462669/
https://ncbi.nlm.nih.gov/pubmed/22726538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-13-52
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