Endothelial Cdkn1a (p21) Overexpression and Accelerated Senescence in a Mouse Model of Fuchs Endothelial Corneal Dystrophy

PURPOSE. Stress of the endoplasmic reticulum and oxidative stress play critical roles in the pathogenesis of Fuchs Endothelial Corneal Dystrophy (FECD). In the normal aging cornea, cellular stress has been associated with a loss in proliferative capacity (premature senescence) of corneal endothelial...

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Main Authors: Matthaei, Mario, Meng, Huan, Meeker, Alan K., Eberhart, Charles G., Jun, Albert S.
Format: Artigo
Language:Inglês
Published: The Association for Research in Vision and Ophthalmology 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3462481/
https://ncbi.nlm.nih.gov/pubmed/22956607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.12-9669
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