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Target binding to S100B reduces dynamic properties and increases Ca(2+)-binding affinity for wild type and EF-hand mutant proteins
Mutations in the second EF-hand (D61N, D63N, D65N, E72A) of S100B were used to study its Ca(2+)-binding and dynamic properties in the absence and presence of abound target, TRTK-12. With (D63N)S100B as an exception ((D63N)K(D) = 50 ± 9 µM), Ca(2+)-binding to EF2-hand mutants were reduced by more tha...
Tallennettuna:
| Päätekijät: | , , , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2012
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3462298/ https://ncbi.nlm.nih.gov/pubmed/22824086 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.07.011 |
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