Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interface

Pemphigus vulgaris (PV) is an autoimmune blistering disease of skin and mucous membranes caused by autoantibodies to the desmoglein (DSG) family proteins DSG3 and DSG1, leading to loss of keratinocyte cell adhesion. To learn more about pathogenic PV autoantibodies, we isolated 15 IgG antibodies spec...

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Detalhes bibliográficos
Main Authors: Di Zenzo, Giovanni, Di Lullo, Giulia, Corti, Davide, Calabresi, Valentina, Sinistro, Anna, Vanzetta, Fabrizia, Didona, Biagio, Cianchini, Giuseppe, Hertl, Michael, Eming, Rudiger, Amagai, Masayuki, Ohyama, Bungo, Hashimoto, Takashi, Sloostra, Jerry, Sallusto, Federica, Zambruno, Giovanna, Lanzavecchia, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3461925/
https://ncbi.nlm.nih.gov/pubmed/22996451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64413
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