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Pathogenesis of follicular lymphoma

The hallmark t(14;18)(q32;q21) in follicular lymphoma (FL) results in constitutive overexpression of the BCL2 protein, allowing B cells to abrogate the default germinal center apoptotic program. Most tumors are characterized by recurrent secondary genetic alterations including genomic gains, losses,...

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Bibliografiske detaljer
Main Authors: Kridel, Robert, Sehn, Laurie H., Gascoyne, Randy D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3461914/
https://ncbi.nlm.nih.gov/pubmed/23023713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI63186
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