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Differentiation-associated microRNAs antagonize the Rb–E2F pathway to restrict proliferation

The cancer-associated loss of microRNA (miRNA) expression leads to a proliferative advantage and aggressive behavior through largely unknown mechanisms. Here, we exploit a model system that recapitulates physiological terminal differentiation and its reversal upon oncogene expression to analyze coor...

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Autors principals: Marzi, Matteo J., Puggioni, Eleonora M. R., Dall'Olio, Valentina, Bucci, Gabriele, Bernard, Loris, Bianchi, Fabrizio, Crescenzi, Marco, Di Fiore, Pier Paolo, Nicassio, Francesco
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2012
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3461518/
https://ncbi.nlm.nih.gov/pubmed/23027903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201206033
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