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Differentiation-associated microRNAs antagonize the Rb–E2F pathway to restrict proliferation
The cancer-associated loss of microRNA (miRNA) expression leads to a proliferative advantage and aggressive behavior through largely unknown mechanisms. Here, we exploit a model system that recapitulates physiological terminal differentiation and its reversal upon oncogene expression to analyze coor...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3461518/ https://ncbi.nlm.nih.gov/pubmed/23027903 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201206033 |
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