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Caspase-1 activity is required to bypass macrophage apoptosis upon Salmonella infection
Here we report AWP28, an activity-based probe that can be used to biochemically monitor caspase-1 activation in response to pro-inflammatory stimuli. Using AWP28 we show that apoptosis is triggered upon bacterial infection in primary murine bone marrow macrophages lacking caspase-1. Furthermore we r...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3461347/ https://ncbi.nlm.nih.gov/pubmed/22797665 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1023 |
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