Induction of pulmonary mucosal immune responses with a protein vaccine targeted to the DEC-205/CD205 receptor

It is of great interest to develop a pneumonic plague vaccine that would induce combined humoral and cellular immunity in the lung. Here we investigate a novel approach based on targeting of dendritic cells using the DEC-205/CD205 receptor (DEC) via the intranasal route as way to improve mucosal cel...

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Main Authors: Do, Yoonkyung, Didierlaurent, Arnaud M., Ryu, Seongho, Koh, Hyein, Park, Chae Gyu, Park, Steven, Perlin, David S., Powell, Bradford S., Steinman, Ralph M.
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3461253/
https://ncbi.nlm.nih.gov/pubmed/22947140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2012.08.051
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