Single amino acid substitution altering antigen-binding specificity.
S107, a phosphocholine-binding myeloma protein, has been cloned in soft agar, and an antigen-binding variant has been isolated and characterized. The variant does not bind phosphocholine attached to carrier or as free hapten in solution but does retain antigenic determinants (idiotypes) of the paren...
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| Published in: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
1982
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC346105/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6804947/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.79.6.1979 |
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