Inhibition of Glycogen Synthase Kinase 3β Ameliorates D-GalN/LPS-Induced Liver Injury by Reducing Endoplasmic Reticulum Stress-Triggered Apoptosis

BACKGROUND: Glycogen synthase kinase 3β(GSK3β) is a ubiquitous serine-threonine protein kinase that participates in numerous cellular processes and disease pathophysiology. We aimed to determine therapeutic potential of GSK3β inhibition and its mechanism in a well-characterized model of lipopolysacc...

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Bibliographic Details
Main Authors: Chen, Liyan, Ren, Feng, Zhang, Haiyan, Wen, Tao, Piao, Zhengfu, Zhou, Li, Zheng, Sujun, Zhang, Jing, Chen, Yu, Han, Yuanping, Duan, Zhongping, Ma, Yingji
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3461002/
https://ncbi.nlm.nih.gov/pubmed/23028846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045202
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