Increased Response to β(2)-Adrenoreceptor Stimulation Augments Inhibition of I(Kr) in Heart Failure Ventricular Myocytes

BACKGROUND: Increasing evidence indicates that the rapid component of delayed rectifier potassium current (I(Kr)) is modulated by α- and β-adrenergic stimulation. However, the role and mechanism regulating I(Kr) through β(2)-adrenoreceptor (β-AR) stimulation in heart failure (HF) are unclear. METHOD...

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Detalhes bibliográficos
Main Authors: Wang, Hegui, Chen, Yanhong, Zhu, Hongjun, Wang, Sen, Zhang, Xiwen, Xu, Dongjie, Cao, Kejiang, Zou, Jiangang
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460863/
https://ncbi.nlm.nih.gov/pubmed/23029432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046186
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