The down-regulation of miR-125b in chronic lymphocytic leukemias leads to metabolic adaptation of cells to a transformed state

MiR-125b-1 maps at 11q24, a chromosomal region close to the epicenter of 11q23 deletions in chronic lymphocytic leukemias (CLLs). Our results establish that both aggressive and indolent CLL patients show reduced expression of miR-125b. Overexpression of miR-125b in CLL-derived cell lines resulted in...

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Hauptverfasser: Tili, Esmerina, Michaille, Jean-Jacques, Luo, Zhenghua, Volinia, Stefano, Rassenti, Laura Z., Kipps, Thomas J., Croce, Carlo M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2012
Schlagworte:
Lymphoid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460685/
https://ncbi.nlm.nih.gov/pubmed/22723551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-03-415737
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