Comparison of Spheroids Formed by Rat Glioma Stem Cells and Neural Stem Cells Reveals Differences in Glucose Metabolism and Promising Therapeutic Applications

Cancer stem cells (CSCs) are thought to be partially responsible for cancer resistance to current therapies and tumor recurrence. Dichloroacetate (DCA), a compound capable of shifting metabolism from glycolysis to glucose oxidation, via an inhibition of pyruvate dehydrogenase kinase was used. We sho...

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Detalhes bibliográficos
Main Authors: Morfouace, Marie, Lalier, Lisenn, Bahut, Muriel, Bonnamain, Virginie, Naveilhan, Philippe, Guette, Catherine, Oliver, Lisa, Gueguen, Naig, Reynier, Pascal, Vallette, Francois M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460464/
https://ncbi.nlm.nih.gov/pubmed/22782899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.320028
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