Role of Binding and Nucleoside Diphosphate Kinase A in the Regulation of the Cystic Fibrosis Transmembrane Conductance Regulator by AMP-activated Protein Kinase

Cystic fibrosis transmembrane conductance regulator (CFTR) Cl(−) channel mutations cause cystic fibrosis lung disease. A better understanding of CFTR regulatory mechanisms could suggest new therapeutic strategies. AMP-activated protein kinase (AMPK) binds to and phosphorylates CFTR, attenuating PKA-...

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Main Authors: King, J Darwin, Lee, Jeffrey, Riemen, Claudia E., Neumann, Dietbert, Xiong, Sheng, Foskett, J. Kevin, Mehta, Anil, Muimo, Richmond, Hallows, Kenneth R.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Membrane Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460441/
https://ncbi.nlm.nih.gov/pubmed/22869372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.396036
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