EGFR-T790M Is a Rare Lung Cancer Susceptibility Allele with Enhanced Kinase Activity

The use of tyrosine kinase inhibitors (TKI) has yielded great success in treatment of lung adenocarcinomas. However, patients who develop resistance to TKI treatment often acquire a somatic resistance mutation (T790M) located in the catalytic cleft of the epidermal growth factor receptor (EGFR) enzy...

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Detalhes bibliográficos
Main Authors: Vikis, Haris, Sato, Mitsuo, James, Michael, Wang, Daolong, Wang, Yian, Wang, Min, Jia, Dongmei, Liu, Yan, Bailey-Wilson, Joan E., Amos, Christopher I., Pinney, Susan M., Petersen, Gloria M., de Andrade, Mariza, Yang, Ping, Wiest, Jonathan S., Fain, Pamela R., Schwartz, Ann G., Gazdar, Adi, Gaba, Colette, Rothschild, Henry, Mandal, Diptasri, Kupert, Elena, Seminara, Daniela, Viswanathan, Avinash, Govindan, Ramaswamy, Minna, John, Anderson, Marshall W., You, Ming
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460269/
https://ncbi.nlm.nih.gov/pubmed/17510392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-0217
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