EGFR-T790M Is a Rare Lung Cancer Susceptibility Allele with Enhanced Kinase Activity

The use of tyrosine kinase inhibitors (TKI) has yielded great success in treatment of lung adenocarcinomas. However, patients who develop resistance to TKI treatment often acquire a somatic resistance mutation (T790M) located in the catalytic cleft of the epidermal growth factor receptor (EGFR) enzy...

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Autori principali: Vikis, Haris, Sato, Mitsuo, James, Michael, Wang, Daolong, Wang, Yian, Wang, Min, Jia, Dongmei, Liu, Yan, Bailey-Wilson, Joan E., Amos, Christopher I., Pinney, Susan M., Petersen, Gloria M., de Andrade, Mariza, Yang, Ping, Wiest, Jonathan S., Fain, Pamela R., Schwartz, Ann G., Gazdar, Adi, Gaba, Colette, Rothschild, Henry, Mandal, Diptasri, Kupert, Elena, Seminara, Daniela, Viswanathan, Avinash, Govindan, Ramaswamy, Minna, John, Anderson, Marshall W., You, Ming
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460269/
https://ncbi.nlm.nih.gov/pubmed/17510392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-0217
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