Transcription factor redundancy and tissue-specific regulation: Evidence from functional and physical network connectivity

Two major transcriptional regulators of Caenorhabditis elegans bodywall muscle (BWM) differentiation, hlh-1 and unc-120, are expressed in muscle where they are known to bind and regulate several well-studied muscle-specific genes. Simultaneously mutating both factors profoundly inhibits formation of...

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Bibliographic Details
Main Authors: Kuntz, Steven G., Williams, Brian A., Sternberg, Paul W., Wold, Barbara J.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2012
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460186/
https://ncbi.nlm.nih.gov/pubmed/22730465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.133306.111
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