Hypoxia Promotes Osteogenesis but Suppresses Adipogenesis of Human Mesenchymal Stromal Cells in a Hypoxia-Inducible Factor-1 Dependent Manner

BACKGROUND: Bone fracture initiates a series of cellular and molecular events including the expression of hypoxia-inducible factor (HIF)-1. HIF-1 is known to facilitate recruitment and differentiation of multipotent human mesenchymal stromal cells (hMSC). Therefore, we analyzed the impact of hypoxia...

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Autors principals: Wagegg, Markus, Gaber, Timo, Lohanatha, Ferenz L., Hahne, Martin, Strehl, Cindy, Fangradt, Monique, Tran, Cam Loan, Schönbeck, Kerstin, Hoff, Paula, Ode, Andrea, Perka, Carsten, Duda, Georg N., Buttgereit, Frank
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3459928/
https://ncbi.nlm.nih.gov/pubmed/23029528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046483
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