A Genotypic Test for HIV-1 Tropism Combining Sanger Sequencing with Ultradeep Sequencing Predicts Virologic Response in Treatment-Experienced Patients

A tropism test is required prior to initiation of CCR5 antagonist therapy in HIV-1 infected individuals, as these agents are not effective in patients harboring CXCR4 (X4) coreceptor-using viral variants. We developed a clinical laboratory-based genotypic tropism test for detection of CCR5-using (R5...

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Detalhes bibliográficos
Main Authors: Kagan, Ron M., Johnson, Erik P., Siaw, Martin, Biswas, Pinaki, Chapman, Douglass S., Su, Zhaohui, Platt, Jamie L., Pesano, Rick L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3459909/
https://ncbi.nlm.nih.gov/pubmed/23029482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046334
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