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Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis

We genotyped 2,861 cases from the UK PBC consortium and 8,514 UK population controls across 196,524 variants within 186 known autoimmune risk loci. We identified three loci newly associated with primary biliary cirrhosis (PBC) (with P<5×10(−8)), increasing the number of known susceptibility loci...

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Autors principals: Liu, Jimmy Z, Almarri, Mohamed A, Gaffney, Daniel J, Mells, George F, Jostins, Luke, Cordell, Heather J, Ducker, Samantha J, Day, Darren B, Heneghan, Michael A, Neuberger, James M., Donaldson, Peter T, Bathgate, Andrew J, Burroughs, Andrew, Davies, Mervyn H, Jones, David E, Alexander, Graeme J, Barrett, Jeffrey C, Sandford, Richard N, Anderson, Carl A
Format: Artigo
Idioma:Inglês
Publicat: 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3459817/
https://ncbi.nlm.nih.gov/pubmed/22961000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2395
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