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Palladium(II)-Catalyzed Enantio- and Diastereoselective Synthesis of Pyrrolidine Derivatives

[Image: see text] A palladium-catalyzed enantio- and diastereoselective synthesis of pyrrolidine derivatives is described. Initial intramolecular nucleopalladation of the tethered protected amine forms the pyrrolidine moiety and a quinone methide intermediate. A second nucleophile adds intermolecula...

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Autori principali: Jana, Ranjan, Pathak, Tejas P., Jensen, Katrina H., Sigman, Matthew S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3459323/
https://ncbi.nlm.nih.gov/pubmed/22873944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol3016989
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