Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked Syndrome: A Paradigm of Immunodeficiency with Autoimmunity

Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a rare monogenic primary immunodeficiency (PID) due to mutations of FOXP3, a key transcription factor for naturally occurring (n) regulatory T (Treg) cells. The dysfunction of Treg cells is the main pathogenic event l...

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Main Authors: Barzaghi, Federica, Passerini, Laura, Bacchetta, Rosa
格式: Artigo
語言:Inglês
出版: Frontiers Research Foundation 2012
主題:
Immunology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3459184/
https://ncbi.nlm.nih.gov/pubmed/23060872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2012.00211
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