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Role of TET2 and ASXL1 mutations in the pathogenesis of myeloproliferative neoplasms

Since the discovery of activating mutations in JAK2 in patients with myeloproliferative neoplasms (MPNs) in 2005, gene discovery efforts have identified additional disease alleles which can predate or occur subsequent to acquisition of JAK2/MPL mutations. In 2009, single nucleotide polymorphism (SNP...

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Detalhes bibliográficos
Main Authors: Abdel-Wahab, Omar, Tefferi, Ayalew, Levine, Ross L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3459179/
https://ncbi.nlm.nih.gov/pubmed/23009937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hoc.2012.07.006
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