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PTEN/Akt Signaling Controls Mitochondrial Respiratory Capacity through 4E-BP1
Akt, a serine/threonine kinase has been shown to stimulate glycolysis in cancer cells but its role in mitochondrial respiration is unknown. Using PTEN-knockout mouse embryonic fibroblasts (MEF(PTEN−/−)) with hyper-activated Akt as a cell model, we observed a higher respiratory capacity in MEF(PTEN−/...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3458951/ https://ncbi.nlm.nih.gov/pubmed/23049865 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045806 |
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