PTEN/Akt Signaling Controls Mitochondrial Respiratory Capacity through 4E-BP1

Akt, a serine/threonine kinase has been shown to stimulate glycolysis in cancer cells but its role in mitochondrial respiration is unknown. Using PTEN-knockout mouse embryonic fibroblasts (MEF(PTEN−/−)) with hyper-activated Akt as a cell model, we observed a higher respiratory capacity in MEF(PTEN−/...

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Bibliografiske detaljer
Main Authors: Goo, Chong Kiat, Lim, Hwee Ying, Ho, Qin Shi, Too, Heng-Phon, Clement, Marie-Veronique, Wong, Kim Ping
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458951/
https://ncbi.nlm.nih.gov/pubmed/23049865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045806
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