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Polynucleotide Phosphorylase Plays an Important Role in the Generation of Spontaneous Mutations in Escherichia coli

Polynucleotide phosphorylase (PNP) plays a central role in RNA degradation, generating a pool of ribonucleoside diphosphates (rNDPs) that can be converted to deoxyribonucleoside diphosphates (dNDPs) by ribonucleotide reductase. We report here that spontaneous mutations resulting from replication err...

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Bibliografiske detaljer
Main Authors: Becket, Elinne, Tse, Lawrence, Yung, Madeline, Cosico, Alexander, Miller, Jeffrey H.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458659/
https://ncbi.nlm.nih.gov/pubmed/22904280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00962-12
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