Involvement of Werner syndrome protein in MUTYH-mediated repair of oxidative DNA damage

Reactive oxygen species constantly generated as by-products of cellular metabolism readily attack genomic DNA creating mutagenic lesions such as 7,8-dihydro-8-oxo-guanine (8-oxo-G) that promote aging. 8-oxo-G:A mispairs arising during DNA replication are eliminated by base excision repair initiated...

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Autori principali: Kanagaraj, Radhakrishnan, Parasuraman, Prasanna, Mihaljevic, Boris, van Loon, Barbara, Burdova, Kamila, König, Christiane, Furrer, Antonia, Bohr, Vilhelm A., Hübscher, Ulrich, Janscak, Pavel
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2012
Soggetti:
Genome Integrity, Repair and Replication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458577/
https://ncbi.nlm.nih.gov/pubmed/22753033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks648
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