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Structural architecture and functional evolution of Wnts
The crystal structure of a Wnt morphogen bound to its Frizzled receptor ectodomain provides insights into the evolutionary provenance of this complex fold, and offers an explanation for why Wnts utilize both lipid- and protein-mediated contacts to engage Frizzleds.
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3458506/ https://ncbi.nlm.nih.gov/pubmed/22898770 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2012.07.011 |
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