Conditional control of gene function by an invertible gene trap in zebrafish

Conditional mutations are essential for determining the stage- and tissue-specific functions of genes. Here we achieve conditional mutagenesis in zebrafish using FT1, a gene-trap cassette that can be stably inverted by both Cre and Flp recombinases. We demonstrate that intronic insertions in the gen...

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Bibliografiske detaljer
Main Authors: Ni, Terri T., Lu, Jianjun, Zhu, Meiying, Maddison, Lisette A., Boyd, Kelli L., Huskey, Lindsey, Ju, Bensheng, Hesselson, Daniel, Zhong, Tao P., Page-McCaw, Patrick S., Stainier, Didier Y., Chen, Wenbiao
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458342/
https://ncbi.nlm.nih.gov/pubmed/22908272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206131109
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