Dietary Linoleic Acid Elevates Endogenous 2-AG and Anandamide and Induces Obesity

Suppressing hyperactive endocannabinoid tone is a critical target for reducing obesity. The backbone of both endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide (AEA) is the ω-6 fatty acid arachidonic acid (AA). Here we posited that excessive dietary intake of linoleic acid (LA), the precu...

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Detalhes bibliográficos
Main Authors: Alvheim, Anita R., Malde, Marian K., Osei-Hyiaman, Douglas, Hong Lin, Yu, Pawlosky, Robert J., Madsen, Lise, Kristiansen, Karsten, Frøyland, Livar, Hibbeln, Joseph R.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Integrative Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458187/
https://ncbi.nlm.nih.gov/pubmed/22334255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oby.2012.38
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