Gliadin Peptides Induce Tissue Transglutaminase Activation and ER-Stress through Ca(2+) Mobilization in Caco-2 Cells

BACKGROUND: Celiac disease (CD) is an intestinal inflammatory condition that develops in genetically susceptible individuals after exposure to dietary wheat gliadin. The role of post-translational modifications of gliadin catalyzed by tissue transglutaminase (tTG) seems to play a crucial role in CD....

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Bibliographic Details
Main Authors: Caputo, Ivana, Secondo, Agnese, Lepretti, Marilena, Paolella, Gaetana, Auricchio, Salvatore, Barone, Maria Vittoria, Esposito, Carla
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458012/
https://ncbi.nlm.nih.gov/pubmed/23049776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045209
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